Hi KB77, ive done this a few times. Myself and DH both had good jobs (no kids then tho) in Reading and we just upped and moved to Brighton. We loved it, but we still had itchy feet so after two years we packed up and went travelling. We ended up back in reading and both got our old jobs back (how lucky!!), but 18 months ago we upped and left and are now in Ireland. Our kids are 4 and 3, and not in school yet so a bit easier for us. We havent sold our house yet but have a family member staying there and helping with the money side. We rent in Ireland and we do plan to go back to reading at some point. It took DH about 18 months to find a job in Ireland. I was home with the kids, so again easier in that respect.
Its not easy tbh, but I do believe in just doing stuff rather than always only talking about it.
Good luck and keep us posted!